Stephen Senn: Blogs and Web Papers

This page provides a link to various blogs of mine and also to papers of mine that are readily available on the web. On the whole the papers are didactic in nature.

A companion page on Data Sets may also be of interest

Blogs and Papers

Type Topic Title Keywords
Blog COVID19 Heard Immunity COVID19; Clinical Trials; Sequential Analysis; Vaccines; Pfizer/BioNTech; AZ/Oxford; Moderna
Blog COVID19 Stimulated to simulate COVID19; Clinical Trials; Sequential Analysis
Blog COVID19 A Vaccine Trial from A to Z COVID19; Clinical Trials; Vaccines; Inference; AZ/Oxford
Blog COVID19 A Vaccine Trial from A to Z: with a Postscript COVID19; Clinical Trials; Vaccines;Inference;AZ/Oxford;Pfizer/BioNTech
Blog COVID19 Doubling Up COVID19; Clinical Trials; Vaccines; Inference; Pfizer/BioNTech; Moderna
Blog COVID19 Infectious Enthusiasm COVID19; Clinical Trials; Vaccines; Inference; Pfizer/BioNTech
Blog COVID19 Serendipity Dividend? COVID19; Clinical Trials; Vaccines;Inference; Dose Response; AZ/Oxford
Blog COVID19 Needlework Guesswork COVID19; Clinical Trials; Vaccines; Inference; Reverse Engineering; AZ/Oxford
Blog COVID19 Complicated COVID comparisons COVID19; Clinical Trials; Vaccines;Inference;AZ/Oxford
Blog COVID19 Of Weighting and Waiting COVID19; Clinical Trials; Vaccines;Inference; AZ/Oxford
Blog COVID19 Blind Date COVID19; Clinical Trials; Vaccines;Inference
Blog COVID19 Beta Testing COVID19; Clinical Trials; Vaccines;Inference; Bayesian; Pfizer/BioNTech
Blog COVID19 Straining for Effect COVID19; Clinical Trials; Vaccines;Inference; New variant COVID-19; Novavax
Blog COVID19 Dilly-Dally Delay? COVID19; Clinical Trials; Vaccines;Inference; AZ/Oxford; Booster shot
Blog COVID19 Credible Confidence COVID19; Clinical Trials; Vaccines;Inference; Pfizer/BioNTech; Bayesian
Blog COVID19 A Very Standard Error COVID19; Clinical Trials; Vaccines;Inference;Pfizer/BioNTech; Moderna; AZ/Oxford; Concurrent Control
Blog COVID19 Phase Change COVID19; Clinical Trials; Vaccines;Inference; AZ/Oxford
Blog COVID19 Hold that Result COVID19; Clinical Trials; Vaccines;Inference; AZ/Oxford
Blog COVID19 Youthful Enthusiasm COVID19; Clinical Trials; Vaccines;Inference; Pfizer/BioNTech
Blog COVID19 Going Viral COVID19; Clinical Trials; Vaccines;Inference; Pfizer/BioNTech; AZ/Oxford; Moderna; Novavax; J&J Janssen
Blog COVID19 Screen Test COVID19; Screening; Bayes theorem; Sensitivity; Specificity; Positive Predictive Value; Negative Predictive Value
Blog COVID19 Indian Summer COVID19; Vaccine Efficacy; Viral Strains; Pfizer/BioNTech; AZ/Oxford; Indian variant
Blog COVID19 Scale Fail COVID19; Vaccine Efficacy; Measurement; Pfizer/BioNTech; AZ/Oxford; Moderna; J&J Janssen; Novavax
Blog COVID19 Trials of COVID-19 vaccines: what can be learnt for the development of new antimicrobials? COVID19; Vaccine Efficacy; Pfizer/BioNTech; AZ/Oxford; Moderna; J&J Janssen; Novavax; Historical controls; Design of Experiments
Blog Evidence Based Medicine It's publishing, Jim, but not as we know it Publication bias; open data
Blog Evidence Based Medicine Fishing for Fakes with FisherFraud; Randomisation
Paper Evidence Based Medicine Publication Bias: Editors are not Blameless after allPublication bias
Paper Evidence Based Medicine Authors are also reviewersPublication bias
Paper Evidence Based Medicine Overstating the EvidenceMeta-analyis; Standard Errors
Paper Evidence Based Medicine Sharp tongues and bitter pillsEthics; Pharmaceutical industry; Meta-analysis; Publication bias; Conflict of Interest
Blog Evidence Based Medicine Open seasonData-sharing
Blog Evidence Based Medicine Is Pooling FoolingMeta-Analysis
Blog Evidence Based Medicine Bad PharmaPharmaceutical industry; Ethics; Missing data; Data filters
Blog Evidence Based Medicine Two CulturesPharmaceutical industry; Drug Regulation; Clinical Trials;Statistical Analysis
Blog Experimental Design Delta ForcePower; Sample size; Clinical trials
Blog Experimental Design Rothamsted Statistics meets Lord's ParadoxCausal Analysis; Components of Variation; Analysis of Variance
Blog Experimental Design On the LevelCausal Analysis; Components of Variation; General Balance;Block Structure; Analysis of Variance
Blog Experimental Design To Infinity and BeyondBig data; Clinical trials; Randomisation; Standard Error; Analysis of Variance
Blog Experimental Design Red Herrings and the Art of Cause FishingCausal Analysis; Components of Variation
Paper Experimental Design The Misunderstood PlaceboEthics; Control; Clinical Trials; Equipoise
Blog Experimental Design Fooling the Patient: an Unethical Use of Placebo?Ethics; Control; Clinical Trials; Equipoise
Blog Experimental Design Placebos: It's not only the Patients that are FooledEthics; Control; Clinical Trials; Equipoise
Paper Experimental Design The AB/BA Cross-over: How to perform the two-stage analysis if you can't be persuaded that you shouldn't Cross-over Trial; Clinical Trials; Carry-Over; Testing Assumptions; Inference
Paper Experimental Design An Incomplete Blocks Trial in Asthma Cross-over Trial; Clinical Trials;Incomplete Blocks; Dose-Finding; Inference Parallel Assay
Paper Experimental Design Lessons from TGN 1412 Clinical Trials; Dose-Finding; Ethics; Trend Effects; Inference; First-in-Man
Paper Experimental Design Safety First Clinical Trials; Dose-Finding; Ethics; Trend Effects; Inference; First-in-Man
Blog Experimental Design Blood simpleBioequivalence; Two-sided tests; One-sided tests; Clinical Trials; Confidence Intervals
Blog Experimental Design Making it personal: N-of-1 trials, allowing for individuality but not overdoing itClinical Trials; Random Effects; Shrinkage; Mixed Models;Personalised Medicine
Blog Experimental Design Testing Times Clinical Trials; Cross-over Trials; Inference; Recogniseable Subsets; Testing Assumptions; Screening
Blog Experimental Design t for Two Drug Development; Clinical Trials; Inference; COVID19; meta-analysis
Blog Experimental Design Designed Inferences Clinical Trials; Inference; Components of Variation; Cross-over Trials
Paper Experimental Design Giving and taking: ethical treatment assignment in controlled trials. (With Iain Chalmers) Clinical Trials; Ethics; Placebos
Paper History Cushny and Peebles, optical isomers, and the birth of modern statistics. Student; t-test; n-of-1 trials
Paper History A century of t-tests Student; t-test; n-of-1 trials
Paper History The t-test tool Student; t-test; n-of-1 trials
Paper History Francis Galton and Regression to the Mean Genetics; Correlation
Paper History Tea for three. Fisher; Randomisation; Blinding; Experimental Design; Inference
Blog Inference Automatic for the people Bayes Factors; Two Trials Rule; Significance
Blog Inference Dawid's Selection Paradox Bayesian; Conjugate Prior; Hierarchical Model
Blog Inference A Paradox of Prior ProbabilitiesBayesian; Conjugate Prior; Hierarchical Model
Blog Inference Fisher's Alternative to the AlternativeHistory of Statistics; Significance Test
Blog Inference Also Smith and Jones Bayesian; Sequential Analysis
Blog Inference The irrelevance of stopping rules in meta-analysisSequential Analysis; Meta-Analysis; Weighting; Evidence
Blog Inference The Pathetic P-valueBayesian; Frequentist; Significance
Blog Inference Double JeopardyBayesian; Frequentist; Significance
Blog Inference When relevance is irrelevant Additivity; Statistical Analysis; Survival Analysis; Numbers Needed to Treat; Personalised Medicine
Paper Inference Bayesian, Likelihood,and FrequentistApproaches to Statistics Tutorial; Bayesian; Frequentist; Clinical Trials; Drug Development
Paper Inference Invalid Inversion Regression to the Mean; Error of the Transposed Conditional; Bayesian
Paper Inference You may Believe you are a Bayesian but you are Probably Wrong Bayesian; Jeffreys; Fisher; De Finetti; Neyman-Pearson
Blog Inference The nuisance parameter nuisance Cross-over trials; Testing assumptions; Pre-testing; Carry-over
Blog Inference The importance of knowing how much you don't know Standard Errors; History of Statistics; Meta-analysis; Confidence Intervals;Experimental Design
Blog Inference Of Amazons, Martingales, Rogue Traders and Sequential Analysis Meta-analysis; Sequential Analysis; Martingales;Clinical trials
Blog Inference Dichotomania Measurement; Efficiency; Information;Clinical trials
Blog Inference Being Wrong about Efficacy Probabilities Clinical trials; Randomisation; Causal Inference; Prediction
Blog Inference Cause for Concern Causal Inference; Mixed models; Design of Experiments; Lord's Paradox
Video Inference What is your question? Causal and predictive purposes of clinical trials and the implications for analysis Causal Inference; Mixed models; Prediction
Video Inference The Many Halls Problem Causal Inference; Mixed models; Lord's Paradox; Design of Experiments
Paper Miscellaneous Comets, Contagion and ContingencyInfectious diseases; Stochastic Processes; Cometary Hypothesis
Blog Personalised Medicine Personal Perils Numbers Needed to Treat; Precision Medicine; Personalised Medicine
Blog Personalised Medicine 30 Years of Numbers Needed to TreatNumbers Needed to Treat; Precision Medicine; Personalised Medicine
Blog Personalised Medicine Painful Dichotomies Numbers Needed to Treat; Precision Medicine; Personalised Medicine; Exponential Distribution; Counterfactual
Program Personalised Medicine NNT Simulator and Calculator Numbers Needed to Treat; Precision Medicine; Personalised Medicine; Exponential Distribution; Counterfactual
Blog Personalised Medicine Responder Despondency Numbers Needed to Treat; Precision Medicine; Personalised Medicine; Exponential Distribution; Counterfactual; Zombie Statistics
Paper Personalised Medicine Statistical pitfalls of personalized medicine Numbers Needed to Treat; Precision Medicine; Personalised Medicine; Exponential Distribution; Counterfactual; Zombie Statistics
Paper Personalised Medicine Three Things Every Medical Writer Should Know About Statistics Regression to the Mean; Invalid Inversion; Precision Medicine; Personalised Medicine;
Paper Personalised Medicine Mastering Variation Responder fallacy; Personalised Medicine; Components of Variation; Quality; Counterfactuals
Blog Personalised Medicine Evidence Based or Person-centred? A Statistical debate (Guest Post) Precision Medicine; Personalised Medicine; Bioequivalence; n-of-1 Trials
Blog Personalised Medicine The Power of Negative Thinking Clinical Trials; Personalised Medicine; Power;Subgroups;Responders;Critical Care
Blog Personalised Medicine Finding excuses Clinical Trials; Personalised Medicine; Power;Subgroups;Responders;Critical Care
Blog Personalised Medicine Invisible Statistics Clinical Trials; Personalised Medicine; Subgroups; Responders; Bioequivalence; Sex inequality
Blog Personalised Medicine Fair Shares: Sexual Justice in Patient Recruitment in Clinical Trials Clinical Trials; Personalised Medicine; Subgroups; Sex inequality; Ethics
Blog Personalised Medicine It's harder than you think Clinical Trials; Personalised Medicine; Responder Analysis
Blog Professional On Being a Consultant (Medical) Statistician Consulting; Pharmaceutical Industry
Blog Randomisation Randomisation, Ratios and RationalityClinical Trials; Analysis of Variance; Randomisation
Paper Randomisation The Well-adjusted StatisticianClinical Trials; Analysis of Covariance; Randomisation
Blog Randomisation Being a statistician means never having to say you are certain Clinical Trials; Analysis of Variance; Randomisation; Causal Analysis
Blog Randomisation Indefinite IrrelevanceClinical Trials; Analysis of Variance; Randomisation; Causal Analysis
Paper Randomisation Baseline Balance and Valid Statistical AnalysesClinical Trials; Analysis of Variance; Randomisation
Blog Randomisation Stop Obesessing about BalanceClinical Trials; Analysis of Variance; Randomisation
Blog Randomisation Being Just about AdjustmentClinical Trials; Analysis of Covariance; Randomisation; Baselines
InterviewRandomisation 70 Years and Still Here: The Randomized Clinical Trial and its CriticsClinical Trials; Analysis of Variance; Randomisation
BlogRandomisation Randomisation is not about balance, nor about homogeneity but about randomnessClinical Trials; Analysis of Variance; Randomisation, Incomplete blocks, Confidence Intervals
BlogRandomisation Balance is not the issueClinical Trials; Analysis of Variance; Randomisation; Incomplete blocks; Confidence Intervals
BlogRandomisation Losing controlClinical Trials; Analysis of Variance; Randomisation; Concurrent Control; Historical Controls; COVID-19
VideoRandomisation Being wrong about randomisationClinical Trials; Analysis of Variance; Randomisation;Uncertainty;Standard Errors
BlogTeaching On thinking and learningUniversities; Undergraduate Education
ProgramTeaching Logistic exam mark rescalerExaminations; Assessment; Logistic Regression

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This page last updated 2 November 2021

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